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Major Groove Substituents and Polymerase Recognition of a Class of Predominantly Hydrophobic Unnatural Base Pairs
Expansion of the genetic alphabet with an unnatural base pair is a long-standing goal of synthetic biology. We have developed a class of unnatural base pairs, formed between d5SICS and analogues of dMMO2, that are efficiently and selectively replicated by the Klenow Fragment (Kf) DNA polymerase. In...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3693734/ https://ncbi.nlm.nih.gov/pubmed/22190386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201102066 |
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