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Optimization of Unnatural Base Pair Packing for Polymerase Recognition

As part of an effort to expand the genetic alphabet, we have been examining the ability of predominately hydrophobic nucleobase analogs to pair in duplex DNA and during polymerase-mediated replication. We previously reported the synthesis and thermal stability of unnatural base pairs formed between...

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Bibliografiske detaljer
Main Authors: Matsuda, Shigeo, Henry, Allison A., Romesberg, Floyd E.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536690/
https://ncbi.nlm.nih.gov/pubmed/16683801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja057575m
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