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Natural-Like Replication of an Unnatural Base Pair for the Expansion of the Genetic Alphabet and Biotechnology Applications

We synthesized a panel of unnatural base pairs whose pairing depends on hydrophobic and packing forces and identify dTPT3-dNaM, which is PCR amplified with a natural base pair-like efficiency and fidelity. In addition, the dTPT3 scaffold is uniquely tolerant of attaching a propargyl amine linker, re...

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書誌詳細
主要な著者: Li, Lingjun, Degardin, Mélissa, Lavergne, Thomas, Malyshev, Denis A., Dhami, Kirandeep, Ordoukhanian, Phillip, Romesberg, Floyd E.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979842/
https://ncbi.nlm.nih.gov/pubmed/24152106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408814g
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