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Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet

The natural four-letter genetic alphabet, comprised of just two base pairs (dA-dT and dG-dC), is conserved throughout all life, and its expansion by the development of a third, unnatural base pair has emerged as a central goal of chemical and synthetic biology. We recently developed a class of candi...

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Bibliographic Details
Main Authors: Malyshev, Denis A., Dhami, Kirandeep, Quach, Henry T., Lavergne, Thomas, Ordoukhanian, Phillip, Torkamani, Ali, Romesberg, Floyd E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409741/
https://ncbi.nlm.nih.gov/pubmed/22773812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205176109
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