Dominant suppression of inflammation by glycan-hydrolyzed IgG

A unique anti-inflammatory property of IgG, independent of antigen specificity, is described. IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-β-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammati...

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Detalhes bibliográficos
Main Authors: Nandakumar, Kutty Selva, Collin, Mattias, Happonen, Kaisa E., Croxford, Allyson M., Lundström, Susanna L., Zubarev, Roman A., Rowley, Merrill J., Blom, Anna M., Holmdahl, Rikard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690874/
https://ncbi.nlm.nih.gov/pubmed/23671108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301480110
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