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Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

Tumor suppressors known to date impede cancer growth by arresting the cell cycle or promoting apoptosis. Here we show that unphosphorylated human STAT5A functions as a tumor suppressor capable of repressing multiple oncogenes via heterochromatin formation. Unphosphorylated STAT5A binds to heterochro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hu, Xiaoyu, Dutta, Pranabananda, Tsurumi, Amy, Li, Jinghong, Wang, Jingtong, Land, Hartmut, Li, Willis X.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690839/
https://ncbi.nlm.nih.gov/pubmed/23733954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221243110
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