Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-(11)C-verapamil and PET

The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at the blood-brain barrier (BBB) and believed to be implicated in resistance to central nervous system drugs. We used small-animal positron emission tomography (PET) and (R)-(11)C-verapamil together with tariq...

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Main Authors: Bankstahl, Jens P., Kuntner, Claudia, Abrahim, Aiman, Karch, Rudolf, Stanek, Johann, Wanek, Thomas, Wadsak, Wolfgang, Kletter, Kurt, Müller, Markus, Löscher, Wolfgang, Langer, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690700/
https://ncbi.nlm.nih.gov/pubmed/18632828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.051235
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