Cytosolic NADPH Homeostasis in Glucose-starved Procyclic Trypanosoma brucei Relies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux

All living organisms depend on NADPH production to feed essential biosyntheses and for oxidative stress defense. Protozoan parasites such as the sleeping sickness pathogen Trypanosoma brucei adapt to different host environments, carbon sources, and oxidative stresses during their infectious life cyc...

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Bibliographische Detailangaben
Hauptverfasser: Allmann, Stefan, Morand, Pauline, Ebikeme, Charles, Gales, Lara, Biran, Marc, Hubert, Jane, Brennand, Ana, Mazet, Muriel, Franconi, Jean-Michel, Michels, Paul A. M., Portais, Jean-Charles, Boshart, Michael, Bringaud, Frédéric
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689991/
https://ncbi.nlm.nih.gov/pubmed/23665470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462978
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