Cytosolic NADPH Homeostasis in Glucose-starved Procyclic Trypanosoma brucei Relies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux

All living organisms depend on NADPH production to feed essential biosyntheses and for oxidative stress defense. Protozoan parasites such as the sleeping sickness pathogen Trypanosoma brucei adapt to different host environments, carbon sources, and oxidative stresses during their infectious life cyc...

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Detalhes bibliográficos
Main Authors: Allmann, Stefan, Morand, Pauline, Ebikeme, Charles, Gales, Lara, Biran, Marc, Hubert, Jane, Brennand, Ana, Mazet, Muriel, Franconi, Jean-Michel, Michels, Paul A. M., Portais, Jean-Charles, Boshart, Michael, Bringaud, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689991/
https://ncbi.nlm.nih.gov/pubmed/23665470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462978
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