Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

Acetyl-CoA produced in mitochondria from carbohydrate or amino acid catabolism needs to reach the cytosol to initiate de novo synthesis of fatty acids. All eukaryotes analyzed so far use a citrate/malate shuttle to transfer acetyl group equivalents from the mitochondrial matrix to the cytosol. Here...

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Bibliographische Detailangaben
Hauptverfasser: Rivière, Loïc, Moreau, Patrick, Allmann, Stefan, Hahn, Matthias, Biran, Marc, Plazolles, Nicolas, Franconi, Jean-Michel, Boshart, Michael, Bringaud, Frédéric
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722340/
https://ncbi.nlm.nih.gov/pubmed/19625628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903355106
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