Revisiting the Central Metabolism of the Bloodstream Forms of Trypanosoma brucei: Production of Acetate in the Mitochondrion Is Essential for Parasite Viability

BACKGROUND: The bloodstream forms of Trypanosoma brucei, the causative agent of sleeping sickness, rely solely on glycolysis for ATP production. It is generally accepted that pyruvate is the major end-product excreted from glucose metabolism by the proliferative long-slender bloodstream forms of the...

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Detalhes bibliográficos
Main Authors: Mazet, Muriel, Morand, Pauline, Biran, Marc, Bouyssou, Guillaume, Courtois, Pierrette, Daulouède, Sylvie, Millerioux, Yoann, Franconi, Jean-Michel, Vincendeau, Philippe, Moreau, Patrick, Bringaud, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868518/
https://ncbi.nlm.nih.gov/pubmed/24367711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002587
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