Age dependency of cerebral P-gp function measured with (R)-[(11)C]verapamil and PET

PURPOSE: The aim of this study was to assess the influence of age on the functional activity of the multidrug efflux transporter P-glycoprotein (P-gp) at the human blood-brain barrier. METHODS: 7 young (mean age: 27±4 years) and 6 elderly (mean age: 69±9 years) healthy volunteers underwent dynamic (...

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Hlavní autoři: Bauer, Martin, Karch, Rudolf, Neumann, Friederike, Abrahim, Aiman, Wagner, Claudia C, Kletter, Kurt, Müller, Markus, Zeitlinger, Markus, Langer, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689922/
https://ncbi.nlm.nih.gov/pubmed/19655132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-009-0709-5
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