A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of (11)C- and (14)C-labelled verapamil in healthy volunteers

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• A combined accelerator mass spectrometry-positron emission tomography human microdose study with (14)C- and (11)C-labelled verapamil
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• A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)–(11)C-verapamil and PET
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• Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-(11)C-verapamil and PET
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• Decreased blood-brain barrier P-glycoprotein function with aging
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