A combined accelerator mass spectrometry-positron emission tomography human microdose study with (14)C- and (11)C-labelled verapamil

BACKGROUND AND OBJECTIVE: In microdose studies, the pharmacokinetic (PK) profile of a drug in blood after administration of a dose up to 100 μg is measured with sensitive analytical techniques, such as accelerator mass spectrometry (AMS). As most drugs exert their effect in tissue rather than blood,...

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Bibliografische gegevens
Hoofdauteurs: Wagner, Claudia C, Simpson, Marie, Zeitlinger, Markus, Bauer, Martin, Karch, Rudolf, Abrahim, Aiman, Feurstein, Thomas, Schütz, Matthias, Kletter, Kurt, Müller, Markus, Lappin, Graham, Langer, Oliver
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763674/
https://ncbi.nlm.nih.gov/pubmed/21142292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2165/11537250-000000000-00000
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