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Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation

Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in development and in pathological conditions such as cancer, retinopathy and ischemic diseases. However, no detailed mass-action models of VEGF receptor signaling have been developed. We constructed and validat...

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Detalhes bibliográficos
Main Authors: Tan, Wan Hua, Popel, Aleksander S., Mac Gabhann, Feilim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689841/
https://ncbi.nlm.nih.gov/pubmed/23805312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067438
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