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Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model

BACKGROUND: VEGF proteolysis by plasmin or matrix metalloproteinases (MMPs) is believed to play an important role in regulating vascular patterning in vivo by releasing VEGF from the extracellular matrix (ECM). However, a quantitative understanding of the kinetics of VEGF cleavage and the efficiency...

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Main Authors: Vempati, Prakash, Mac Gabhann, Feilim, Popel, Aleksander S.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912330/
https://ncbi.nlm.nih.gov/pubmed/20686621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011860
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