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Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model
BACKGROUND: VEGF proteolysis by plasmin or matrix metalloproteinases (MMPs) is believed to play an important role in regulating vascular patterning in vivo by releasing VEGF from the extracellular matrix (ECM). However, a quantitative understanding of the kinetics of VEGF cleavage and the efficiency...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912330/ https://ncbi.nlm.nih.gov/pubmed/20686621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011860 |
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