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Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin
Epitopes for a panel of anti-αVβ3 monoclonal antibodies (mAbs) were investigated to explore the activation mechanism of αVβ3 integrin. Experiments utilizing αV/αIIb domain-swapping chimeras revealed that among the nine mAbs tested, five recognized the ligand-binding β-propeller domain and four recog...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688720/ https://ncbi.nlm.nih.gov/pubmed/23840404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066096 |
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