Structural Requirements for Activation in αIIbβ3 Integrin

Integrins are postulated to undergo structural rearrangement from a low affinity bent conformer to a high affinity extended conformer upon activation. However, some reports have shown that a bent conformer is capable of binding a ligand, whereas another report has shown that integrin extension does...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kamata, Tetsuji, Handa, Makoto, Ito, Sonomi, Sato, Yukiko, Ohtani, Toshimitsu, Kawai, Yohko, Ikeda, Yasuo, Aiso, Sadakazu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992275/
https://ncbi.nlm.nih.gov/pubmed/20884611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139667
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