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Kinetic Proofreading at Single Molecular Level: Aminoacylation of tRNA(Ile) and the Role of Water as an Editor
Proofreading/editing in protein synthesis is essential for accurate translation of information from the genetic code. In this article we present a theoretical investigation of efficiency of a kinetic proofreading mechanism that employs hydrolysis of the wrong substrate as the discriminatory step in...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688713/ https://ncbi.nlm.nih.gov/pubmed/23840412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066112 |
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