Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease

The 5-Lipoxygenase (5LO) is upregulated in Alzheimer’s disease (AD), and in vivo modulates the amyloidotic phenotype of APP transgenic mice. However, no data are available on the effects that 5LO has on synaptic function, integrity and cognition. To address this issue we used a genetic and a pharmac...

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Main Authors: Giannopoulos, Phillip F., Chu, Jin, Joshi, Yash B., Sperow, Margaret, Li, Jin-Luo, Kirby, Lynn G., Praticò, Domenico
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688674/
https://ncbi.nlm.nih.gov/pubmed/23478745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.23
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