Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease

The 5-Lipoxygenase (5LO) is upregulated in Alzheimer’s disease (AD), and in vivo modulates the amyloidotic phenotype of APP transgenic mice. However, no data are available on the effects that 5LO has on synaptic function, integrity and cognition. To address this issue we used a genetic and a pharmac...

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Hauptverfasser: Giannopoulos, Phillip F., Chu, Jin, Joshi, Yash B., Sperow, Margaret, Li, Jin-Luo, Kirby, Lynn G., Praticò, Domenico
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688674/
https://ncbi.nlm.nih.gov/pubmed/23478745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.23
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