Regulated recycling of mutant CFTR is partially restored by pharmacological treatment

Efficient trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) to and from the cell surface is essential for maintaining channel density at the plasma membrane (PM) and ensuring proper physiological activity. The most common mutation, F508del, exhibits reduced surface expres...

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Detaylı Bibliyografya
Asıl Yazarlar: Holleran, John P., Zeng, Jianxin, Frizzell, Raymond A., Watkins, Simon C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687701/
https://ncbi.nlm.nih.gov/pubmed/23572510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.120196
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