Slowing ribosome velocity restores folding and function of mutant CFTR

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), with approximately 90% of patients harboring at least one copy of the disease-associated variant F508del. We utilized a yeast phenomic system to identify genetic modifiers of F508del-CFTR biogenesis, fr...

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Publicado en:J Clin Invest
Autores principales: Oliver, Kathryn E., Rauscher, Robert, Mijnders, Marjolein, Wang, Wei, Wolpert, Matthew J., Maya, Jessica, Sabusap, Carleen M., Kesterson, Robert A., Kirk, Kevin L., Rab, Andras, Braakman, Ineke, Hong, Jeong S., Hartman, John L., Ignatova, Zoya, Sorscher, Eric J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877332/
https://ncbi.nlm.nih.gov/pubmed/31657788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124282
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