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Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators
W1282X is a common nonsense mutation among cystic fibrosis patients that results in the production of a truncated Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Here we show that the channel activity of the W1282X-CFTR polypeptide is exceptionally low in excised membrane patches...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4805204/ https://ncbi.nlm.nih.gov/pubmed/27007499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152232 |
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