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ATP-independent CFTR channel gating and allosteric modulation by phosphorylation
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked to ATP binding and dimerization of its two nucleotide binding domains (NBDs). Channel activation also requires phosp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840504/ https://ncbi.nlm.nih.gov/pubmed/20133716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913001107 |
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