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Neuropeptide Y (NPY): Genetic Variation in the Human Promoter Alters Glucocorticoid Signaling, Yielding Increased NPY Secretion and Stress Responses

OBJECTIVES: This study sought to understand whether genetic variation at the Neuropeptide Y (NPY) locus governs secretion and stress responses in vivo as well as NPY gene expression in sympathochromaffin cells. BACKGROUND: The NPY is a potent pressor peptide co-released with catecholamines during st...

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Detalhes bibliográficos
Main Authors: Zhang, Kuixing, Rao, Fangwen, Miramontes-Gonzalez, Jose Pablo, Hightower, C. Makena, Vaught, Brian, Chen, Yuhong, Greenwood, Tiffany A., Schork, Andrew J., Wang, Lei, Mahata, Manjula, Stridsberg, Mats, Khandrika, Srikrishna, Biswas, Nilima, Fung, Maple M., Waalen, Jill, Middelberg, Rita P., Heath, Andrew C., Montgomery, Grant W., Martin, Nicholas G., Whitfield, John B., Baker, Dewleen G., Schork, Nicholas J., Nievergelt, Caroline M., O’Connor, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687554/
https://ncbi.nlm.nih.gov/pubmed/23021333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2012.06.042
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