Neuropeptide Y(1) receptor NPY1R: Discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo

BACKGROUND: Neuropeptide Y (NPY) interacts with the Y(1) receptor, NPY1R, to control adrenergic activity and BP. We asked whether naturally occurring genetic variation at the human NPY1R locus alters autonomic traits that might predispose individuals to cardiovascular disease. METHODS AND RESULTS: W...

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Hlavní autoři: Wang, Lei, Rao, Fangwen, Zhang, Kuixing, Mahata, Manjula, Rodriguez-Flores, Juan L., Fung, Maple M., Waalen, Jill, Cockburn, Myles G., Hamilton, Bruce A., Mahata, Sushil K., O'Connor., Daniel T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792636/
https://ncbi.nlm.nih.gov/pubmed/19712806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2009.05.035
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