Common Charge-Shift Mutation Glu65Lys in K(+) Channel β(1)-Subunit KCNMB1: Pleiotropic Consequences for Glomerular Filtration Rate and Progressive Renal Disease

BACKGROUND: Glomerular filtration rate (GFR) is a heritable trait, and hyperfiltration (GFR increment in remnant nephrons) may accelerate renal functional decline in chronic kidney disease (CKD). Mesangial and vascular smooth myocytes control GFR by contraction, dependent on voltage-gated Ca(2+) inf...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen, Yuqing, Salem, Rany M., Rao, Fangwen, Fung, Maple M., Bhatnagar, Vibha, Pandey, Braj, Mahata, Manjula, Waalen, Jill, Nievergelt, Caroline M., Lipkowitz, Michael S., Hamilton, Bruce A., Mahata, Sushil K., O'Connor, Daniel T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: S. Karger AG 2010
Pynciau:
Original Report: Patient-Oriented, Translational Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975731/
https://ncbi.nlm.nih.gov/pubmed/20861615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000320131
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