Common Charge-Shift Mutation Glu65Lys in K(+) Channel β(1)-Subunit KCNMB1: Pleiotropic Consequences for Glomerular Filtration Rate and Progressive Renal Disease

BACKGROUND: Glomerular filtration rate (GFR) is a heritable trait, and hyperfiltration (GFR increment in remnant nephrons) may accelerate renal functional decline in chronic kidney disease (CKD). Mesangial and vascular smooth myocytes control GFR by contraction, dependent on voltage-gated Ca(2+) inf...

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Auteurs principaux: Chen, Yuqing, Salem, Rany M., Rao, Fangwen, Fung, Maple M., Bhatnagar, Vibha, Pandey, Braj, Mahata, Manjula, Waalen, Jill, Nievergelt, Caroline M., Lipkowitz, Michael S., Hamilton, Bruce A., Mahata, Sushil K., O'Connor, Daniel T.
Format: Artigo
Langue:Inglês
Publié: S. Karger AG 2010
Sujets:
Original Report: Patient-Oriented, Translational Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975731/
https://ncbi.nlm.nih.gov/pubmed/20861615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000320131
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