Common Charge-Shift Mutation Glu65Lys in K(+) Channel β(1)-Subunit KCNMB1: Pleiotropic Consequences for Glomerular Filtration Rate and Progressive Renal Disease

BACKGROUND: Glomerular filtration rate (GFR) is a heritable trait, and hyperfiltration (GFR increment in remnant nephrons) may accelerate renal functional decline in chronic kidney disease (CKD). Mesangial and vascular smooth myocytes control GFR by contraction, dependent on voltage-gated Ca(2+) inf...

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Detalhes bibliográficos
Main Authors: Chen, Yuqing, Salem, Rany M., Rao, Fangwen, Fung, Maple M., Bhatnagar, Vibha, Pandey, Braj, Mahata, Manjula, Waalen, Jill, Nievergelt, Caroline M., Lipkowitz, Michael S., Hamilton, Bruce A., Mahata, Sushil K., O'Connor, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Original Report: Patient-Oriented, Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975731/
https://ncbi.nlm.nih.gov/pubmed/20861615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000320131
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