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Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

Signal transduction networks in mammalian cells, comprised of a limited set of interacting biochemical pathways, are accessed by various growth factor and cytokine receptors to elicit distinct cell responses. This raises the question as to how specificity of the stimulus-response relationship is enc...

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Bibliografski detalji
Glavni autori: Cirit, Murat, Haugh, Jason M.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687362/
https://ncbi.nlm.nih.gov/pubmed/21943356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110833
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