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Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and nucleocytoplasmic shuttling, which allows active ERK to...

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Bibliografiske detaljer
Main Authors: Ahmed, Shoeb, Grant, Kyle G, Edwards, Laura E, Rahman, Anisur, Cirit, Murat, Goshe, Michael B, Haugh, Jason M
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023404/
https://ncbi.nlm.nih.gov/pubmed/24489118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/msb.134708
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