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Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states
The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback, and nucleocytoplasmic shuttling, which allows active ERK to...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4023404/ https://ncbi.nlm.nih.gov/pubmed/24489118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/msb.134708 |
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