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Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation
Signal transduction networks in mammalian cells, comprised of a limited set of interacting biochemical pathways, are accessed by various growth factor and cytokine receptors to elicit distinct cell responses. This raises the question as to how specificity of the stimulus-response relationship is enc...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687362/ https://ncbi.nlm.nih.gov/pubmed/21943356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110833 |
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