Mucoadhesive Fenretinide Patches for Site-specific Chemoprevention of Oral Cancer: Enhancement of Oral Mucosal Permeation of Fenretinide by Co-incorporation of Propylene Glycol and Menthol

The objective of this study was to enhance oral mucosal permeation of fenretinide by co-incorporation of propylene glycol (PG) and menthol in fenretinide/Eudragit® RL PO mucoadhesive patches. Fenretinide is an extremely hydrophobic chemopreventive compound with poor tissue permeability. Co-incorpora...

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Autors principals: Wu, Xiao, Desai, Kashappa-Goud H., Mallery, Susan R., Holpuch, Andrew S., Phelps, Maynard P., Schwendeman, Steven P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687357/
https://ncbi.nlm.nih.gov/pubmed/22280430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200655k
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