Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention

Systemic delivery of fenretinide in oral cancer chemoprevention trials has been largely unsuccessful due to dose-limiting toxicities and subtherapeutic intraoral drug levels. Local drug delivery, however, provides site-specific therapeutically relevant levels while minimizing systemic exposure. Thes...

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Detalhes bibliográficos
Main Authors: Holpuch, Andrew S., Phelps, Maynard P., Desai, Kashappa-Goud H., Chen, Wei, Koutras, George M., Han, Byungdo B., Warner, Blake M., Pei, Ping, Seghi, Garrett A., Tong, Meng, Border, Michael B., Fields, Henry W., Stoner, Gary D., Larsen, Peter E., Liu, Zhongfa, Schwendeman, Steven P., Mallery, Susan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Inflammation, Microenvironment and Prevention
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334520/
https://ncbi.nlm.nih.gov/pubmed/22427354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs122
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