Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention

Systemic delivery of fenretinide in oral cancer chemoprevention trials has been largely unsuccessful due to dose-limiting toxicities and subtherapeutic intraoral drug levels. Local drug delivery, however, provides site-specific therapeutically relevant levels while minimizing systemic exposure. Thes...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Holpuch, Andrew S., Phelps, Maynard P., Desai, Kashappa-Goud H., Chen, Wei, Koutras, George M., Han, Byungdo B., Warner, Blake M., Pei, Ping, Seghi, Garrett A., Tong, Meng, Border, Michael B., Fields, Henry W., Stoner, Gary D., Larsen, Peter E., Liu, Zhongfa, Schwendeman, Steven P., Mallery, Susan R.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Inflammation, Microenvironment and Prevention
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334520/
https://ncbi.nlm.nih.gov/pubmed/22427354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs122
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki