Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter

Transforming growth factor (TGF)-β upregulates plasminogen activator inhibitor type 1 (PAI-1) in a variety of cell types, and PAI-1 is considered to be an essential factor for the development of fibrosis. Our previous studies demonstrated that TGF-β decreased intracellular glutathione (GSH) content...

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Bibliographic Details
Main Authors: Vayalil, Praveen K., Iles, Karen E., Choi, Jinah, Yi, Ae-Kyung, Postlethwait, Edward M., Liu, Rui-Ming
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686828/
https://ncbi.nlm.nih.gov/pubmed/17890327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00128.2007
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