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Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter
Transforming growth factor (TGF)-β upregulates plasminogen activator inhibitor type 1 (PAI-1) in a variety of cell types, and PAI-1 is considered to be an essential factor for the development of fibrosis. Our previous studies demonstrated that TGF-β decreased intracellular glutathione (GSH) content...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3686828/ https://ncbi.nlm.nih.gov/pubmed/17890327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00128.2007 |
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