Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation

Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes—multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contribut...

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Detalhes bibliográficos
Main Authors: Lippai, Dora, Bala, Shashi, Petrasek, Jan, Csak, Timea, Levin, Ivan, Kurt-Jones, Evelyn A., Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2013
Assuntos:
Host Defense & Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685015/
https://ncbi.nlm.nih.gov/pubmed/23625200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1212659
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