Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→6)–linked poly-N-acetyl-d-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designa...

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Detalhes bibliográficos
Main Authors: Cywes-Bentley, Colette, Skurnik, David, Zaidi, Tanweer, Roux, Damien, DeOliveira, Rosane B., Garrett, Wendy S., Lu, Xi, O’Malley, Jennifer, Kinzel, Kathryn, Zaidi, Tauqeer, Rey, Astrid, Perrin, Christophe, Fichorova, Raina N., Kayatani, Alexander K. K., Maira-Litràn, Tomas, Gening, Marina L., Tsvetkov, Yury E., Nifantiev, Nikolay E., Bakaletz, Lauren O., Pelton, Stephen I., Golenbock, Douglas T., Pier, Gerald B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683766/
https://ncbi.nlm.nih.gov/pubmed/23716675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303573110
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