Myofilament calcium de-sensitization and contractile uncoupling prevents pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction

Myocardial infarction (MI) is a major risk for ventricular arrhythmia. Pause-triggered ventricular arrhythmia can be caused by increased myofilament Ca binding due to sarcomeric mutations or Ca-sensitizing compounds. Myofilament Ca sensitivity is also increased after MI. Here we hypothesize that MI...

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Main Authors: Venkataraman, Raghav, Baldo, Marcelo Perim, Hwang, Hyun-Seok, Veltri, Tiago, Pinto, Jose Renato, Baudenbacher, Franz J., Knollmann, Bjorn C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683590/
https://ncbi.nlm.nih.gov/pubmed/23570978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.03.022
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