Just Getting Into Cells is Not Enough: Mechanisms Underlying 4-(N)-Stearoyl Gemcitabine Solid Lipid Nanoparticle's Ability to Overcome Gemcitabine Resistance Caused by RRM1 Overexpression

Gemcitabine is a deoxycytidine analog that is widely used in the chemotherapy of many solid tumors. However, acquired tumor cell resistance often limits its use. Previously, we discovered that 4-(N)-stearoyl gemcitabine solid lipid nanoparticles (4-(N)-GemC18-SLNs) can overcome multiple acquired gem...

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Main Authors: Wonganan, Piyanuch, Lansakara-P, Dharmika S. P., Zhu, Saijie, Holzer, Melisande, Sandoval, Michael A., Warthaka, Mangalika, Cui, Zhengrong
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683387/
https://ncbi.nlm.nih.gov/pubmed/23570983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.03.033
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