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Just Getting Into Cells is Not Enough: Mechanisms Underlying 4-(N)-Stearoyl Gemcitabine Solid Lipid Nanoparticle's Ability to Overcome Gemcitabine Resistance Caused by RRM1 Overexpression
Gemcitabine is a deoxycytidine analog that is widely used in the chemotherapy of many solid tumors. However, acquired tumor cell resistance often limits its use. Previously, we discovered that 4-(N)-stearoyl gemcitabine solid lipid nanoparticles (4-(N)-GemC18-SLNs) can overcome multiple acquired gem...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683387/ https://ncbi.nlm.nih.gov/pubmed/23570983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.03.033 |
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