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Progranulin Deficiency Exaggerates, whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice
PGRN and its derived engineered protein, Atsttrin, were reported to antagonize TNFα and protect against inflammatory arthritis (Tang, W., et al, Science, 2011). Here we found that PGRN level was also significantly elevated in skin inflammation. PGRN−/− mice exhibited more severe inflammation followi...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683372/ https://ncbi.nlm.nih.gov/pubmed/23669357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.04.037 |
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