Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

BACKGROUND: Atsttrin, an engineered protein composed of three tumor necrosis factor receptor (TNFR)-binding fragments of progranulin (PGRN), shows therapeutic effect in multiple murine models of inflammatory arthritis . Additionally, intra-articular delivery of PGRN protects against osteoarthritis (...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Wei, Jian-lu, Fu, Wenyu, Ding, Yuan-jing, Hettinghouse, Aubryanna, Lendhey, Matin, Schwarzkopf, Ran, Kennedy, Oran D., Liu, Chuan-ju
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735869/
https://ncbi.nlm.nih.gov/pubmed/29258611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1485-8
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