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Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes
Multifunctional factor progranulin (PGRN) plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD). The first breakthrough in understanding the molecular mechanisms of P...
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| 發表在: | Genes Dis |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Chongqing Medical University
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5609500/ https://ncbi.nlm.nih.gov/pubmed/28944282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2017.05.001 |
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