Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes

Multifunctional factor progranulin (PGRN) plays an important role in lysosomes, and its mutations and insufficiency are associated with lysosomal storage diseases, including neuronal ceroid lipofuscinosis and Gaucher disease (GD). The first breakthrough in understanding the molecular mechanisms of P...

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Bibliografiske detaljer
Udgivet i:Genes Dis
Main Authors: Jian, Jinlong, Hettinghouse, Aubryanna, Liu, Chuan-ju
Format: Artigo
Sprog:Inglês
Udgivet: Chongqing Medical University 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609500/
https://ncbi.nlm.nih.gov/pubmed/28944282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2017.05.001
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