VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations

Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle, and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia, myopathy, Paget’s disease or a combination of these. The disease mechanism is unknown. We developed a Drosophila model of VCP mutat...

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Bibliografiske detaljer
Main Authors: Kim, Nam Chul, Tresse, Emilie, Kolaitis, Regina M., Molliex, Amandine, Thomas, Ruth E., Alami, Nael H., Wang, Bo, Joshi, Aashish, Smith, Rebecca B., Ritson, Gillian P., Winborn, Brett J., Moore, Jennifer, Lee, Joo-Yong, Yao, Tso-Pang, Pallanck, Leo, Kundu, Mondira, Taylor, J. Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683300/
https://ncbi.nlm.nih.gov/pubmed/23498974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.029
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