VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations

Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle, and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia, myopathy, Paget’s disease or a combination of these. The disease mechanism is unknown. We developed a Drosophila model of VCP mutat...

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Autors principals: Kim, Nam Chul, Tresse, Emilie, Kolaitis, Regina M., Molliex, Amandine, Thomas, Ruth E., Alami, Nael H., Wang, Bo, Joshi, Aashish, Smith, Rebecca B., Ritson, Gillian P., Winborn, Brett J., Moore, Jennifer, Lee, Joo-Yong, Yao, Tso-Pang, Pallanck, Leo, Kundu, Mondira, Taylor, J. Paul
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683300/
https://ncbi.nlm.nih.gov/pubmed/23498974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.029
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