VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations

Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle, and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia, myopathy, Paget’s disease or a combination of these. The disease mechanism is unknown. We developed a Drosophila model of VCP mutat...

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主要な著者: Kim, Nam Chul, Tresse, Emilie, Kolaitis, Regina M., Molliex, Amandine, Thomas, Ruth E., Alami, Nael H., Wang, Bo, Joshi, Aashish, Smith, Rebecca B., Ritson, Gillian P., Winborn, Brett J., Moore, Jennifer, Lee, Joo-Yong, Yao, Tso-Pang, Pallanck, Leo, Kundu, Mondira, Taylor, J. Paul
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683300/
https://ncbi.nlm.nih.gov/pubmed/23498974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.029
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