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Effects of N(2)-Alkylguanine, O(6)-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-Family DNA Polymerase Vent (exo(−))
Archaeal and eukaryotic B-family DNA polymerases (pols) mainly replicate chromosomal DNA but stall at lesions, which are often bypassed with Y-family pols. In this study, a B-family pol Vent (exo(−)) from the euryarchaeon Thermococcus litoralis was studied with three types of DNA lesions—N(2)-alkylG...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683241/ https://ncbi.nlm.nih.gov/pubmed/22793782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300168p |
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