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Translesion Synthesis Across Abasic Lesions by Human B-family and Y-family DNA Polymerases α, δ, η, ι, κ, and REV1

Abasic (AP) sites are the most common DNA lesions formed in cells, induce severe blocks to DNA replication, and are highly mutagenic. Human Y-family translesion DNA polymerases (pols) such as pols η, ι, κ, and REV1 have been suggested to play roles in replicative bypass across many DNA lesions where...

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Detalhes bibliográficos
Main Authors: Choi, Jeong-Yun, Lim, Seonhee, Kim, Eun-Jin, Jo, Ara, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018708/
https://ncbi.nlm.nih.gov/pubmed/20888339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.015
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