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PDE4 in the human heart – major player or little helper?
PDEs restrict the positive inotropic effects of β-adrenoceptor stimulation by degrading cAMP. Hence, PDE inhibitors sensitize the heart to catecholamines and are therefore used as positive inotropes. On the downside, this is accompanied by exaggerated energy expenditure, cell death and arrhythmias....
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Blackwell Publishing Ltd
2013
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682701/ https://ncbi.nlm.nih.gov/pubmed/23489196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12168 |
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