Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PDE4 inhibitors, each belonging to one of two classe...

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Detalhes bibliográficos
Main Authors: Manning, Carol D, Burman, Miriam, Christensen, Siegfried B, Cieslinski, Lenora B, Essayan, David M, Grous, Marilyn, Torphy, Theodore J, Barnette, Mary S
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571768/
https://ncbi.nlm.nih.gov/pubmed/10602317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702911
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