Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

The deubiquitinase CYLD acts as a key negative regulator to tightly control overactive inflammation. Most anti-inflammatory strategies have focused on directly targeting the positive regulator, which often results in significant side effects such as suppression of the host defence response. Here, we...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Komatsu, Kensei, Lee, Ji-Yun, Miyata, Masanori, Hyang Lim, Jae, Jono, Hirofumi, Koga, Tomoaki, Xu, Haidong, Yan, Chen, Kai, Hirofumi, Li, Jian-Dong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644066/
https://ncbi.nlm.nih.gov/pubmed/23575688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2674
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk