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Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

The deubiquitinase CYLD acts as a key negative regulator to tightly control overactive inflammation. Most anti-inflammatory strategies have focused on directly targeting the positive regulator, which often results in significant side effects such as suppression of the host defence response. Here, we...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Komatsu, Kensei, Lee, Ji-Yun, Miyata, Masanori, Hyang Lim, Jae, Jono, Hirofumi, Koga, Tomoaki, Xu, Haidong, Yan, Chen, Kai, Hirofumi, Li, Jian-Dong
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Pub. Group 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644066/
https://ncbi.nlm.nih.gov/pubmed/23575688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2674
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