Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

The deubiquitinase CYLD acts as a key negative regulator to tightly control overactive inflammation. Most anti-inflammatory strategies have focused on directly targeting the positive regulator, which often results in significant side effects such as suppression of the host defence response. Here, we...

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Autori principali: Komatsu, Kensei, Lee, Ji-Yun, Miyata, Masanori, Hyang Lim, Jae, Jono, Hirofumi, Koga, Tomoaki, Xu, Haidong, Yan, Chen, Kai, Hirofumi, Li, Jian-Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644066/
https://ncbi.nlm.nih.gov/pubmed/23575688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2674
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