Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses

A novel, potent, and highly specific inhibitor of calcium-calmodulin-dependent phosphodiesterases (PDE) of the PDE1 family, ITI-214, was used to investigate the role of PDE1 in inflammatory responses. ITI-214 dose-dependently suppressed lipopolysaccharide (LPS)-induced gene expression of pro-inflamm...

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Pubblicato in:Mol Cell Neurosci
Autori principali: O'Brien, Jennifer J., O'Callaghan, James P., Miller, Diane B., Chalgeri, Suman, Wennogle, Lawrence P., Davis, Robert E., Snyder, Gretchen L., Hendrick, Joseph P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783477/
https://ncbi.nlm.nih.gov/pubmed/31770590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.103449
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